ATP-dependent RNA helicase DDX25 (DDX25)
Homo sapiens — UniProt Q9UHL0
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent RNA helicase DDX25 (DDX25) is a protein from Homo sapiens identified by UniProt accession Q9UHL0, 483 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.
- UniProt accession: Q9UHL0; gene symbol DDX25.
- Organism: Homo sapiens.
- Length: 483 amino acids.
- Top disease associations (Open Targets): azoospermia, sitting height measurement and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent RNA helicase DDX25 |
|---|---|
| UniProt accession | Q9UHL0 |
| Gene | DDX25 |
| Organism | Homo sapiens |
| Length | 483 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (109)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.35
- sitting height measurement · score 0.09
- FEV/FVC ratio · score 0.08
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failures 50 · score 0.06
- spermatogenic failure 25 · score 0.06
- spermatogenic failure, X-linked, 2 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failure 63 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHL0-F1 | alphafold | PREDICTED | 80.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHL0.
Amino-acid sequence (483 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX25?
The strongest Open Targets associations for DDX25 are azoospermia, sitting height measurement, FEV/FVC ratio, partial chromosome Y deletion and male infertility with teratozoospermia due to single gene mutation.
How long is the DDX25 protein?
The Homo sapiens DDX25 protein (UniProt Q9UHL0) is 483 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHL0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHL0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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