General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1)
Homo sapiens — UniProt Q9UHL9
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1) is a protein from Homo sapiens identified by UniProt accession Q9UHL9, 959 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q9UHL9; gene symbol GTF2IRD1.
- Organism: Homo sapiens.
- Length: 959 amino acids.
- Top disease associations (Open Targets): systemic lupus erythematosus, neuroticism measurement and influenza A (H1N1).
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor II-I repeat domain-containing protein 1 |
|---|---|
| UniProt accession | Q9UHL9 |
| Gene | GTF2IRD1 |
| Organism | Homo sapiens |
| Length | 959 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- systemic lupus erythematosus · score 0.40
- neuroticism measurement · score 0.35
- influenza A (H1N1) · score 0.30
- suicide behaviour measurement · score 0.29
- Rare pervasive developmental disorder · score 0.27
- autism spectrum disorder symptom · score 0.11
- rheumatoid arthritis · score 0.07
- pachyonychia congenita · score 0.07
- blood protein measurement · score 0.05
- triglyceride measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHL9-F1 | alphafold | PREDICTED | 63.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHL9.
Amino-acid sequence (959 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF2IRD1?
The strongest Open Targets associations for GTF2IRD1 are systemic lupus erythematosus, neuroticism measurement, influenza A (H1N1), suicide behaviour measurement and Rare pervasive developmental disorder.
How long is the GTF2IRD1 protein?
The Homo sapiens GTF2IRD1 protein (UniProt Q9UHL9) is 959 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHL9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHL9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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