DNA polymerase subunit gamma-2 (POLG2)
Homo sapiens — UniProt Q9UHN1
Data last refreshed: (UniProt release unknown)
Key facts
DNA polymerase subunit gamma-2 (POLG2) is a protein from Homo sapiens identified by UniProt accession Q9UHN1, 485 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q9UHN1; gene symbol POLG2.
- Organism: Homo sapiens.
- Length: 485 amino acids.
- Top disease associations (Open Targets): progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 4, mitochondrial dna depletion syndrome 16B (neuroophthalmic type) and mitochondrial DNA depletion syndrome 16 (hepatic type).
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA polymerase subunit gamma-2 |
|---|---|
| UniProt accession | Q9UHN1 |
| Gene | POLG2 |
| Organism | Homo sapiens |
| Length | 485 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 4 · score 0.74
- mitochondrial dna depletion syndrome 16B (neuroophthalmic type) · score 0.68
- mitochondrial DNA depletion syndrome 16 (hepatic type) · score 0.67
- neurodegenerative disease · score 0.46
- autosomal dominant progressive external ophthalmoplegia · score 0.37
- heel bone mineral density · score 0.31
- forced expiratory volume · score 0.29
- age at menopause · score 0.27
- Acute hepatic failure · score 0.27
- acute liver failure · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHN1-F1 | alphafold | PREDICTED | 80.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHN1.
Amino-acid sequence (485 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLG2?
The strongest Open Targets associations for POLG2 are progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 4, mitochondrial dna depletion syndrome 16B (neuroophthalmic type), mitochondrial DNA depletion syndrome 16 (hepatic type), neurodegenerative disease and autosomal dominant progressive external ophthalmoplegia.
How long is the POLG2 protein?
The Homo sapiens POLG2 protein (UniProt Q9UHN1) is 485 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHN1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHN1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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