Radial spoke head 14 homolog (RSPH14)
Homo sapiens — UniProt Q9UHP6
Data last refreshed: (UniProt release unknown)
Key facts
Radial spoke head 14 homolog (RSPH14) is a protein from Homo sapiens identified by UniProt accession Q9UHP6, 348 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9UHP6; gene symbol RSPH14.
- Organism: Homo sapiens.
- Length: 348 amino acids.
- Top disease associations (Open Targets): nephrolithiasis, neurofibrillary tangles measurement and urolithiasis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Radial spoke head 14 homolog |
|---|---|
| UniProt accession | Q9UHP6 |
| Gene | RSPH14 |
| Organism | Homo sapiens |
| Length | 348 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- nephrolithiasis · score 0.35
- neurofibrillary tangles measurement · score 0.30
- urolithiasis · score 0.28
- heel bone mineral density · score 0.27
- bone density · score 0.25
- lower urinary tract calculus · score 0.21
- handedness · score 0.21
- creatinine clearance measurement · score 0.20
- parathyroid hormone measurement · score 0.10
- vitamin D measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHP6-F1 | alphafold | PREDICTED | 92.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHP6.
Amino-acid sequence (348 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RSPH14?
The strongest Open Targets associations for RSPH14 are nephrolithiasis, neurofibrillary tangles measurement, urolithiasis, heel bone mineral density and bone density.
How long is the RSPH14 protein?
The Homo sapiens RSPH14 protein (UniProt Q9UHP6) is 348 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHP6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHP6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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