Nuclear prelamin A recognition factor (NARF)
Homo sapiens — UniProt Q9UHQ1
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear prelamin A recognition factor (NARF) is a protein from Homo sapiens identified by UniProt accession Q9UHQ1, 456 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q9UHQ1; gene symbol NARF.
- Organism: Homo sapiens.
- Length: 456 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear prelamin A recognition factor |
|---|---|
| UniProt accession | Q9UHQ1 |
| Gene | NARF |
| Organism | Homo sapiens |
| Length | 456 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- platelet count · score 0.04
- protein measurement · score 0.04
- Immature Reticulocyte Fraction Measurement · score 0.03
- ovarian carcinoma · score 0.02
- Abnormal sperm morphology · score 0.02
- multiple sclerosis · score 0.01
- papillary renal cell carcinoma · score 0.01
- transitional cell carcinoma of kidney · score 0.01
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHQ1-F1 | alphafold | PREDICTED | 83.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHQ1.
Amino-acid sequence (456 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NARF?
The strongest Open Targets associations for NARF are neurodegenerative disease, platelet count, protein measurement, Immature Reticulocyte Fraction Measurement and ovarian carcinoma.
How long is the NARF protein?
The Homo sapiens NARF protein (UniProt Q9UHQ1) is 456 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHQ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHQ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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