NADH-cytochrome b5 reductase 1 (CYB5R1)
Homo sapiens — UniProt Q9UHQ9
Data last refreshed: (UniProt release unknown)
Key facts
NADH-cytochrome b5 reductase 1 (CYB5R1) is a protein from Homo sapiens identified by UniProt accession Q9UHQ9, 305 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9UHQ9; gene symbol CYB5R1.
- Organism: Homo sapiens.
- Length: 305 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, neurodegenerative disease and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NADH-cytochrome b5 reductase 1 |
|---|---|
| UniProt accession | Q9UHQ9 |
| Gene | CYB5R1 |
| Organism | Homo sapiens |
| Length | 305 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.25
- neurodegenerative disease · score 0.16
- glioblastoma multiforme · score 0.14
- neoplasm · score 0.08
- gonorrhea · score 0.04
- BMI-adjusted waist-hip ratio · score 0.04
- cancer · score 0.02
- waist-hip ratio · score 0.02
- Dravet syndrome · score 0.01
- Duane retraction syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHQ9-F1 | alphafold | PREDICTED | 94.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHQ9.
Amino-acid sequence (305 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYB5R1?
The strongest Open Targets associations for CYB5R1 are breast adenocarcinoma, neurodegenerative disease, glioblastoma multiforme, neoplasm and gonorrhea.
How long is the CYB5R1 protein?
The Homo sapiens CYB5R1 protein (UniProt Q9UHQ9) is 305 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHQ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHQ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.