Zinc finger HIT domain-containing protein 2 (ZNHIT2)
Homo sapiens — UniProt Q9UHR6
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger HIT domain-containing protein 2 (ZNHIT2) is a protein from Homo sapiens identified by UniProt accession Q9UHR6, 403 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: Q9UHR6; gene symbol ZNHIT2.
- Organism: Homo sapiens.
- Length: 403 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, MODY and diabetes mellitus, permanent neonatal 4.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger HIT domain-containing protein 2 |
|---|---|
| UniProt accession | Q9UHR6 |
| Gene | ZNHIT2 |
| Organism | Homo sapiens |
| Length | 403 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- MODY · score 0.04
- diabetes mellitus, permanent neonatal 4 · score 0.03
- infection · score 0.01
- infect · score 0.01
- acute lymphoblastic leukemia · score 0.00
- endometriosis · score 0.00
- neoplasm · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHR6-F1 | alphafold | PREDICTED | 78.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHR6.
Amino-acid sequence (403 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNHIT2?
The strongest Open Targets associations for ZNHIT2 are neurodegenerative disease, MODY, diabetes mellitus, permanent neonatal 4, infection and infect.
How long is the ZNHIT2 protein?
The Homo sapiens ZNHIT2 protein (UniProt Q9UHR6) is 403 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHR6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHR6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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