Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1)
Homo sapiens — UniProt Q9UHV5
Data last refreshed: (UniProt release unknown)
Key facts
Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1) is a protein from Homo sapiens identified by UniProt accession Q9UHV5, 662 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.
- UniProt accession: Q9UHV5; gene symbol RAPGEFL1.
- Organism: Homo sapiens.
- Length: 662 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, leukocyte count and body weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rap guanine nucleotide exchange factor-like 1 |
|---|---|
| UniProt accession | Q9UHV5 |
| Gene | RAPGEFL1 |
| Organism | Homo sapiens |
| Length | 662 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- leukocyte count · score 0.29
- body weight · score 0.27
- eosinophil count · score 0.25
- self reported educational attainment · score 0.21
- mean corpuscular hemoglobin · score 0.20
- mathematical ability · score 0.19
- mean corpuscular hemoglobin concentration · score 0.16
- high density lipoprotein cholesterol measurement · score 0.14
- monocyte count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHV5-F1 | alphafold | PREDICTED | 75.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHV5.
Amino-acid sequence (662 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RAPGEFL1?
The strongest Open Targets associations for RAPGEFL1 are neurodegenerative disease, leukocyte count, body weight, eosinophil count and self reported educational attainment.
How long is the RAPGEFL1 protein?
The Homo sapiens RAPGEFL1 protein (UniProt Q9UHV5) is 662 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHV5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHV5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.