Galactoside-binding soluble lectin 13 (LGALS13)
Homo sapiens — UniProt Q9UHV8
Data last refreshed: (UniProt release unknown)
Key facts
Galactoside-binding soluble lectin 13 (LGALS13) is a protein from Homo sapiens identified by UniProt accession Q9UHV8, 139 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.
- UniProt accession: Q9UHV8; gene symbol LGALS13.
- Organism: Homo sapiens.
- Length: 139 amino acids.
- Top disease associations (Open Targets): preeclampsia, Familial hemophagocytic lymphohistiocytosis and Felty's syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Galactoside-binding soluble lectin 13 |
|---|---|
| UniProt accession | Q9UHV8 |
| Gene | LGALS13 |
| Organism | Homo sapiens |
| Length | 139 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (164)
Diseases linked to this target (Open Targets).
- preeclampsia · score 0.11
- Familial hemophagocytic lymphohistiocytosis · score 0.05
- Felty's syndrome · score 0.05
- immunodeficiency 72 with autoinflammation · score 0.05
- hyper-IgM syndrome type 3 · score 0.05
- osteoarthritis · score 0.05
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.05
- glycoprotein storage disease · score 0.05
- gestational diabetes · score 0.05
- common variable immunodeficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHV8-F1 | alphafold | PREDICTED | 97.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHV8.
Amino-acid sequence (139 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LGALS13?
The strongest Open Targets associations for LGALS13 are preeclampsia, Familial hemophagocytic lymphohistiocytosis, Felty's syndrome, immunodeficiency 72 with autoinflammation and hyper-IgM syndrome type 3.
How long is the LGALS13 protein?
The Homo sapiens LGALS13 protein (UniProt Q9UHV8) is 139 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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