Prefoldin subunit 2 (PFDN2)
Homo sapiens — UniProt Q9UHV9
Data last refreshed: (UniProt release unknown)
Key facts
Prefoldin subunit 2 (PFDN2) is a protein from Homo sapiens identified by UniProt accession Q9UHV9, 154 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9UHV9; gene symbol PFDN2.
- Organism: Homo sapiens.
- Length: 154 amino acids.
- Top disease associations (Open Targets): head and neck squamous cell carcinoma, glioblastoma multiforme and esophageal cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prefoldin subunit 2 |
|---|---|
| UniProt accession | Q9UHV9 |
| Gene | PFDN2 |
| Organism | Homo sapiens |
| Length | 154 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.23
- glioblastoma multiforme · score 0.23
- esophageal cancer · score 0.23
- appendicular lean mass · score 0.11
- Gorham-Stout disease · score 0.07
- neurodegenerative disease · score 0.06
- melorheostosis · score 0.05
- gonorrhea · score 0.04
- cancer · score 0.03
- mathematical ability · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHV9-F1 | alphafold | PREDICTED | 79.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHV9.
Amino-acid sequence (154 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PFDN2?
The strongest Open Targets associations for PFDN2 are head and neck squamous cell carcinoma, glioblastoma multiforme, esophageal cancer, appendicular lean mass and Gorham-Stout disease.
How long is the PFDN2 protein?
The Homo sapiens PFDN2 protein (UniProt Q9UHV9) is 154 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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