GPN-loop GTPase 3 (GPN3)
Homo sapiens — UniProt Q9UHW5
Data last refreshed: (UniProt release unknown)
Key facts
GPN-loop GTPase 3 (GPN3) is a protein from Homo sapiens identified by UniProt accession Q9UHW5, 284 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9UHW5; gene symbol GPN3.
- Organism: Homo sapiens.
- Length: 284 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and calcium measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPN-loop GTPase 3 |
|---|---|
| UniProt accession | Q9UHW5 |
| Gene | GPN3 |
| Organism | Homo sapiens |
| Length | 284 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- body mass index · score 0.11
- calcium measurement · score 0.08
- QT interval · score 0.08
- Headache · score 0.08
- body height · score 0.07
- schizophrenia · score 0.06
- bipolar disorder · score 0.06
- erythrocyte count · score 0.05
- cognitive function measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHW5-F1 | alphafold | PREDICTED | 86.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHW5.
Amino-acid sequence (284 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPN3?
The strongest Open Targets associations for GPN3 are neurodegenerative disease, body mass index, calcium measurement, QT interval and Headache.
How long is the GPN3 protein?
The Homo sapiens GPN3 protein (UniProt Q9UHW5) is 284 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHW5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHW5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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