Solute carrier family 12 member 6 (SLC12A6)
Homo sapiens — UniProt Q9UHW9
Data last refreshed: (UniProt release unknown)
Key facts
Solute carrier family 12 member 6 (SLC12A6) is a protein from Homo sapiens identified by UniProt accession Q9UHW9, 1150 residues long. MolForge cross-references it against 0 known binders and 227 disease associations.
- UniProt accession: Q9UHW9; gene symbol SLC12A6.
- Organism: Homo sapiens.
- Length: 1150 amino acids.
- Top disease associations (Open Targets): agenesis of the corpus callosum with peripheral neuropathy, Corpus callosum agenesis - neuronopathy and Charcot-Marie-Tooth disease, axonal, IIa 2II.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Solute carrier family 12 member 6 |
|---|---|
| UniProt accession | Q9UHW9 |
| Gene | SLC12A6 |
| Organism | Homo sapiens |
| Length | 1150 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (227)
Diseases linked to this target (Open Targets).
- agenesis of the corpus callosum with peripheral neuropathy · score 0.82
- Corpus callosum agenesis - neuronopathy · score 0.75
- Charcot-Marie-Tooth disease, axonal, IIa 2II · score 0.67
- genetic disorder · score 0.47
- peripheral neuropathy · score 0.33
- mean platelet volume · score 0.27
- Agenesis of corpus callosum · score 0.27
- Clinodactyly of the 5th finger · score 0.27
- Low-set ears · score 0.27
- Hypertelorism · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHW9-F1 | alphafold | PREDICTED | 79.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHW9.
Amino-acid sequence (1150 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC12A6?
The strongest Open Targets associations for SLC12A6 are agenesis of the corpus callosum with peripheral neuropathy, Corpus callosum agenesis - neuronopathy, Charcot-Marie-Tooth disease, axonal, IIa 2II, genetic disorder and peripheral neuropathy.
How long is the SLC12A6 protein?
The Homo sapiens SLC12A6 protein (UniProt Q9UHW9) is 1150 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHW9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHW9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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