Poly(U)-binding-splicing factor PUF60 (PUF60)
Homo sapiens — UniProt Q9UHX1
Data last refreshed: (UniProt release unknown)
Key facts
Poly(U)-binding-splicing factor PUF60 (PUF60) is a protein from Homo sapiens identified by UniProt accession Q9UHX1, 559 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.
- UniProt accession: Q9UHX1; gene symbol PUF60.
- Organism: Homo sapiens.
- Length: 559 amino acids.
- Top disease associations (Open Targets): 8q24.3 microdeletion syndrome, intellectual disability-cardiac anomalies-short stature-joint laxity syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Poly(U)-binding-splicing factor PUF60 |
|---|---|
| UniProt accession | Q9UHX1 |
| Gene | PUF60 |
| Organism | Homo sapiens |
| Length | 559 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- 8q24.3 microdeletion syndrome · score 0.78
- intellectual disability-cardiac anomalies-short stature-joint laxity syndrome · score 0.58
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.52
- syndromic intellectual disability · score 0.46
- Intellectual disability · score 0.37
- neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities · score 0.27
- CHARGE syndrome · score 0.26
- Neurodevelopmental abnormality · score 0.26
- chronic lymphocytic leukemia · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHX1-F1 | alphafold | PREDICTED | 67.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHX1.
Amino-acid sequence (559 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PUF60?
The strongest Open Targets associations for PUF60 are 8q24.3 microdeletion syndrome, intellectual disability-cardiac anomalies-short stature-joint laxity syndrome, neurodegenerative disease, genetic disorder and syndromic intellectual disability.
How long is the PUF60 protein?
The Homo sapiens PUF60 protein (UniProt Q9UHX1) is 559 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.