Adhesion G protein-coupled receptor E2 (ADGRE2)
Homo sapiens — UniProt Q9UHX3
Data last refreshed: (UniProt release unknown)
Key facts
Adhesion G protein-coupled receptor E2 (ADGRE2) is a protein from Homo sapiens identified by UniProt accession Q9UHX3, 823 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q9UHX3; gene symbol ADGRE2.
- Organism: Homo sapiens.
- Length: 823 amino acids.
- Target class: GPCR.
- Top disease associations (Open Targets): vibratory urticaria, autosomal dominant vibratory urticaria and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adhesion G protein-coupled receptor E2 |
|---|---|
| UniProt accession | Q9UHX3 |
| Gene | ADGRE2 |
| Organism | Homo sapiens |
| Length | 823 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | GPCR (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- vibratory urticaria · score 0.52
- autosomal dominant vibratory urticaria · score 0.37
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- low grade glioma · score 0.10
- X-linked severe congenital neutropenia · score 0.06
- Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency · score 0.06
- Recurrent infection due to specific granule deficiency · score 0.06
- neutropenia, severe congenital, 1, autosomal dominant · score 0.05
- nonimmune chronic idiopathic neutropenia of adults · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHX3-F1 | alphafold | PREDICTED | 79.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHX3.
Amino-acid sequence (823 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADGRE2?
The strongest Open Targets associations for ADGRE2 are vibratory urticaria, autosomal dominant vibratory urticaria, ovarian cancer, glioblastoma multiforme and low grade glioma.
How long is the ADGRE2 protein?
The Homo sapiens ADGRE2 protein (UniProt Q9UHX3) is 823 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHX3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHX3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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