Nuclear receptor-binding protein (NRBP1)
Homo sapiens — UniProt Q9UHY1
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear receptor-binding protein (NRBP1) is a protein from Homo sapiens identified by UniProt accession Q9UHY1, 535 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q9UHY1; gene symbol NRBP1.
- Organism: Homo sapiens.
- Length: 535 amino acids.
- Target class: Nuclear receptor.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and age at menopause.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear receptor-binding protein |
|---|---|
| UniProt accession | Q9UHY1 |
| Gene | NRBP1 |
| Organism | Homo sapiens |
| Length | 535 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Nuclear receptor (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- neuroinflammatory disorder · score 0.24
- age at menopause · score 0.12
- neoplasm · score 0.10
- hair color · score 0.09
- hair colour measurement · score 0.08
- triple-negative breast cancer · score 0.07
- triglyceride measurement · score 0.07
- breast cancer · score 0.07
- blood phosphate measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHY1-F1 | alphafold | PREDICTED | 75.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHY1.
Amino-acid sequence (535 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NRBP1?
The strongest Open Targets associations for NRBP1 are neurodegenerative disease, neuroinflammatory disorder, age at menopause, neoplasm and hair color.
How long is the NRBP1 protein?
The Homo sapiens NRBP1 protein (UniProt Q9UHY1) is 535 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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