Fasciculation and elongation protein zeta-2 (FEZ2)
Homo sapiens — UniProt Q9UHY8
Data last refreshed: (UniProt release unknown)
Key facts
Fasciculation and elongation protein zeta-2 (FEZ2) is a protein from Homo sapiens identified by UniProt accession Q9UHY8, 353 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9UHY8; gene symbol FEZ2.
- Organism: Homo sapiens.
- Length: 353 amino acids.
- Top disease associations (Open Targets): body fat percentage, body height and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fasciculation and elongation protein zeta-2 |
|---|---|
| UniProt accession | Q9UHY8 |
| Gene | FEZ2 |
| Organism | Homo sapiens |
| Length | 353 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- body fat percentage · score 0.36
- body height · score 0.35
- lean body mass · score 0.35
- body mass index · score 0.35
- neurodegenerative disease · score 0.31
- body weight · score 0.31
- high density lipoprotein cholesterol measurement · score 0.31
- BMI-adjusted waist circumference · score 0.30
- fat body mass · score 0.28
- vital capacity · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UHY8-F1 | alphafold | PREDICTED | 70.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UHY8.
Amino-acid sequence (353 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FEZ2?
The strongest Open Targets associations for FEZ2 are body fat percentage, body height, lean body mass, body mass index and neurodegenerative disease.
How long is the FEZ2 protein?
The Homo sapiens FEZ2 protein (UniProt Q9UHY8) is 353 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UHY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UHY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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