Rab5 GDP/GTP exchange factor (RABGEF1)
Homo sapiens — UniProt Q9UJ41
Data last refreshed: (UniProt release unknown)
Key facts
Rab5 GDP/GTP exchange factor (RABGEF1) is a protein from Homo sapiens identified by UniProt accession Q9UJ41, 491 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9UJ41; gene symbol RABGEF1.
- Organism: Homo sapiens.
- Length: 491 amino acids.
- Top disease associations (Open Targets): central corneal thickness, Parkinson disease and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rab5 GDP/GTP exchange factor |
|---|---|
| UniProt accession | Q9UJ41 |
| Gene | RABGEF1 |
| Organism | Homo sapiens |
| Length | 491 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- central corneal thickness · score 0.22
- Parkinson disease · score 0.19
- leukocyte count · score 0.16
- glomerular filtration rate · score 0.14
- neutrophil count · score 0.13
- cotinine glucuronidation measurement · score 0.11
- creatinine measurement · score 0.08
- neoplasm · score 0.08
- neutrophil percentage of leukocytes · score 0.07
- aspartate aminotransferase measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJ41-F1 | alphafold | PREDICTED | 77.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJ41.
Amino-acid sequence (491 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RABGEF1?
The strongest Open Targets associations for RABGEF1 are central corneal thickness, Parkinson disease, leukocyte count, glomerular filtration rate and neutrophil count.
How long is the RABGEF1 protein?
The Homo sapiens RABGEF1 protein (UniProt Q9UJ41) is 491 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJ41 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJ41 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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