MAGE-like protein 2 (MAGEL2)
Homo sapiens — UniProt Q9UJ55
Data last refreshed: (UniProt release unknown)
Key facts
MAGE-like protein 2 (MAGEL2) is a protein from Homo sapiens identified by UniProt accession Q9UJ55, 1249 residues long. MolForge cross-references it against 0 known binders and 269 disease associations.
- UniProt accession: Q9UJ55; gene symbol MAGEL2.
- Organism: Homo sapiens.
- Length: 1249 amino acids.
- Top disease associations (Open Targets): Schaaf-Yang syndrome, Prader-Willi syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | MAGE-like protein 2 |
|---|---|
| UniProt accession | Q9UJ55 |
| Gene | MAGEL2 |
| Organism | Homo sapiens |
| Length | 1249 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (269)
Diseases linked to this target (Open Targets).
- Schaaf-Yang syndrome · score 0.79
- Prader-Willi syndrome · score 0.60
- genetic disorder · score 0.53
- arthrogryposis multiplex congenita · score 0.37
- Neurodevelopmental disorder · score 0.37
- Prader-Willi-like syndrome · score 0.37
- Prader-Willi syndrome due to point mutation · score 0.37
- Neurodevelopmental delay · score 0.34
- Ventriculomegaly · score 0.34
- Ambiguous genitalia · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJ55-F1 | alphafold | PREDICTED | 43.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJ55.
Amino-acid sequence (1249 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAGEL2?
The strongest Open Targets associations for MAGEL2 are Schaaf-Yang syndrome, Prader-Willi syndrome, genetic disorder, arthrogryposis multiplex congenita and Neurodevelopmental disorder.
How long is the MAGEL2 protein?
The Homo sapiens MAGEL2 protein (UniProt Q9UJ55) is 1249 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJ55 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJ55 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.