Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (KCNE5)
Homo sapiens — UniProt Q9UJ90
Data last refreshed: (UniProt release unknown)
Key facts
Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (KCNE5) is a protein from Homo sapiens identified by UniProt accession Q9UJ90, 142 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.
- UniProt accession: Q9UJ90; gene symbol KCNE5.
- Organism: Homo sapiens.
- Length: 142 amino acids.
- Top disease associations (Open Targets): Brugada syndrome, Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis and Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium voltage-gated channel subfamily E regulatory beta subunit 5 |
|---|---|
| UniProt accession | Q9UJ90 |
| Gene | KCNE5 |
| Organism | Homo sapiens |
| Length | 142 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (126)
Diseases linked to this target (Open Targets).
- Brugada syndrome · score 0.22
- Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis · score 0.19
- Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome · score 0.19
- lung adenocarcinoma · score 0.10
- Arrhythmogenic right ventricular dysplasia · score 0.10
- hypertrophic cardiomyopathy · score 0.09
- Romano-Ward syndrome · score 0.09
- cardiac conduction defect · score 0.08
- Familial short QT syndrome · score 0.08
- catecholaminergic polymorphic ventricular tachycardia 4 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJ90-F1 | alphafold | PREDICTED | 62.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJ90.
Amino-acid sequence (142 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNE5?
The strongest Open Targets associations for KCNE5 are Brugada syndrome, Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis, Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome, lung adenocarcinoma and Arrhythmogenic right ventricular dysplasia.
How long is the KCNE5 protein?
The Homo sapiens KCNE5 protein (UniProt Q9UJ90) is 142 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJ90 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJ90 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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