Cohesin subunit SA-3 (STAG3)
Homo sapiens — UniProt Q9UJ98
Data last refreshed: (UniProt release unknown)
Key facts
Cohesin subunit SA-3 (STAG3) is a protein from Homo sapiens identified by UniProt accession Q9UJ98, 1225 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: Q9UJ98; gene symbol STAG3.
- Organism: Homo sapiens.
- Length: 1225 amino acids.
- Top disease associations (Open Targets): primary ovarian insufficiency, spermatogenic failure 61 and Premature ovarian insufficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cohesin subunit SA-3 |
|---|---|
| UniProt accession | Q9UJ98 |
| Gene | STAG3 |
| Organism | Homo sapiens |
| Length | 1225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.66
- spermatogenic failure 61 · score 0.59
- Premature ovarian insufficiency · score 0.46
- azoospermia · score 0.39
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.39
- premature menopause · score 0.37
- female infertility · score 0.27
- ovarian disease · score 0.27
- head and neck squamous cell carcinoma · score 0.23
- breast adenocarcinoma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJ98-F1 | alphafold | PREDICTED | 77.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJ98.
Amino-acid sequence (1225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with STAG3?
The strongest Open Targets associations for STAG3 are primary ovarian insufficiency, spermatogenic failure 61, Premature ovarian insufficiency, azoospermia and male infertility with azoospermia or oligozoospermia due to single gene mutation.
How long is the STAG3 protein?
The Homo sapiens STAG3 protein (UniProt Q9UJ98) is 1225 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJ98 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJ98 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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