DNA helicase MCM8 (MCM8)
Homo sapiens — UniProt Q9UJA3
Data last refreshed: (UniProt release unknown)
Key facts
DNA helicase MCM8 (MCM8) is a protein from Homo sapiens identified by UniProt accession Q9UJA3, 840 residues long. MolForge cross-references it against 0 known binders and 225 disease associations.
- UniProt accession: Q9UJA3; gene symbol MCM8.
- Organism: Homo sapiens.
- Length: 840 amino acids.
- Top disease associations (Open Targets): primary ovarian insufficiency, age at menopause and uterine fibroid.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA helicase MCM8 |
|---|---|
| UniProt accession | Q9UJA3 |
| Gene | MCM8 |
| Organism | Homo sapiens |
| Length | 840 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (225)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.65
- age at menopause · score 0.51
- uterine fibroid · score 0.45
- premature menopause · score 0.37
- Premature ovarian insufficiency · score 0.37
- azoospermia · score 0.35
- menopause · score 0.33
- breast carcinoma · score 0.33
- estradiol measurement · score 0.33
- anti-Mullerian hormone measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJA3-F1 | alphafold | PREDICTED | 75.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJA3.
Amino-acid sequence (840 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MCM8?
The strongest Open Targets associations for MCM8 are primary ovarian insufficiency, age at menopause, uterine fibroid, premature menopause and Premature ovarian insufficiency.
How long is the MCM8 protein?
The Homo sapiens MCM8 protein (UniProt Q9UJA3) is 840 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJA3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJA3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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