tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (TRMT6)
Homo sapiens — UniProt Q9UJA5
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (TRMT6) is a protein from Homo sapiens identified by UniProt accession Q9UJA5, 497 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9UJA5; gene symbol TRMT6.
- Organism: Homo sapiens.
- Length: 497 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hepatocellular carcinoma and snoring measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 |
|---|---|
| UniProt accession | Q9UJA5 |
| Gene | TRMT6 |
| Organism | Homo sapiens |
| Length | 497 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- hepatocellular carcinoma · score 0.10
- snoring measurement · score 0.08
- facial morphology measurement · score 0.07
- neoplasm · score 0.06
- age at menopause · score 0.06
- body fat distribution · score 0.06
- heel bone mineral density · score 0.05
- bone quantitative ultrasound measurement · score 0.04
- colorectal cancer · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJA5-F1 | alphafold | PREDICTED | 79.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJA5.
Amino-acid sequence (497 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRMT6?
The strongest Open Targets associations for TRMT6 are neurodegenerative disease, hepatocellular carcinoma, snoring measurement, facial morphology measurement and neoplasm.
How long is the TRMT6 protein?
The Homo sapiens TRMT6 protein (UniProt Q9UJA5) is 497 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJA5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJA5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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