Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5)
Homo sapiens — UniProt Q9UJA9
Data last refreshed: (UniProt release unknown)
Key facts
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (ENPP5) is a protein from Homo sapiens identified by UniProt accession Q9UJA9, 477 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q9UJA9; gene symbol ENPP5.
- Organism: Homo sapiens.
- Length: 477 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, IGF-1 measurement and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 |
|---|---|
| UniProt accession | Q9UJA9 |
| Gene | ENPP5 |
| Organism | Homo sapiens |
| Length | 477 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- IGF-1 measurement · score 0.31
- blood protein measurement · score 0.24
- platelet component distribution width · score 0.24
- mean corpuscular volume · score 0.13
- mean reticulocyte volume · score 0.12
- nose morphology measurement · score 0.05
- MODY · score 0.04
- body mass index · score 0.04
- breast carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJA9-F1 | alphafold | PREDICTED | 88.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJA9.
Amino-acid sequence (477 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ENPP5?
The strongest Open Targets associations for ENPP5 are neurodegenerative disease, IGF-1 measurement, blood protein measurement, platelet component distribution width and mean corpuscular volume.
How long is the ENPP5 protein?
The Homo sapiens ENPP5 protein (UniProt Q9UJA9) is 477 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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