Kelch-like protein 21 (KLHL21)
Homo sapiens — UniProt Q9UJP4
Data last refreshed: (UniProt release unknown)
Key facts
Kelch-like protein 21 (KLHL21) is a protein from Homo sapiens identified by UniProt accession Q9UJP4, 597 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q9UJP4; gene symbol KLHL21.
- Organism: Homo sapiens.
- Length: 597 amino acids.
- Top disease associations (Open Targets): body fat percentage, hypertension and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch-like protein 21 |
|---|---|
| UniProt accession | Q9UJP4 |
| Gene | KLHL21 |
| Organism | Homo sapiens |
| Length | 597 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- body fat percentage · score 0.31
- hypertension · score 0.31
- heel bone mineral density · score 0.27
- FEV/FVC ratio · score 0.26
- clear cell renal carcinoma · score 0.18
- body mass index · score 0.17
- type 2 diabetes mellitus · score 0.16
- sex hormone-binding globulin measurement · score 0.16
- mean reticulocyte volume · score 0.14
- Agents acting on the renin-angiotensin system use measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJP4-F1 | alphafold | PREDICTED | 90.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJP4.
Amino-acid sequence (597 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHL21?
The strongest Open Targets associations for KLHL21 are body fat percentage, hypertension, heel bone mineral density, FEV/FVC ratio and clear cell renal carcinoma.
How long is the KLHL21 protein?
The Homo sapiens KLHL21 protein (UniProt Q9UJP4) is 597 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJP4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJP4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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