Testis-specific serine kinase substrate (TSKS)
Homo sapiens — UniProt Q9UJT2
Data last refreshed: (UniProt release unknown)
Key facts
Testis-specific serine kinase substrate (TSKS) is a protein from Homo sapiens identified by UniProt accession Q9UJT2, 592 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q9UJT2; gene symbol TSKS.
- Organism: Homo sapiens.
- Length: 592 amino acids.
- Top disease associations (Open Targets): neuroinflammatory disorder, urate measurement and myoepithelial tumor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Testis-specific serine kinase substrate |
|---|---|
| UniProt accession | Q9UJT2 |
| Gene | TSKS |
| Organism | Homo sapiens |
| Length | 592 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.29
- urate measurement · score 0.25
- myoepithelial tumor · score 0.11
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failure 72 · score 0.08
- spermatogenic failure 18 · score 0.08
- spermatogenic failure 27 · score 0.08
- spermatogenic failure 46 · score 0.08
- partial chromosome Y deletion · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJT2-F1 | alphafold | PREDICTED | 64.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJT2.
Amino-acid sequence (592 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TSKS?
The strongest Open Targets associations for TSKS are neuroinflammatory disorder, urate measurement, myoepithelial tumor, azoospermia and male infertility with teratozoospermia due to single gene mutation.
How long is the TSKS protein?
The Homo sapiens TSKS protein (UniProt Q9UJT2) is 592 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJT2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJT2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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