Lymphoid enhancer-binding factor 1 (LEF1)
Homo sapiens — UniProt Q9UJU2
Data last refreshed: (UniProt release unknown)
Key facts
Lymphoid enhancer-binding factor 1 (LEF1) is a protein from Homo sapiens identified by UniProt accession Q9UJU2, 399 residues long. MolForge cross-references it against 0 known binders and 488 disease associations.
- UniProt accession: Q9UJU2; gene symbol LEF1.
- Organism: Homo sapiens.
- Length: 399 amino acids.
- Top disease associations (Open Targets): Ectrodactyly, split hand-foot malformation and Split hand-split foot malformation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lymphoid enhancer-binding factor 1 |
|---|---|
| UniProt accession | Q9UJU2 |
| Gene | LEF1 |
| Organism | Homo sapiens |
| Length | 399 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (488)
Diseases linked to this target (Open Targets).
- Ectrodactyly · score 0.43
- split hand-foot malformation · score 0.43
- Split hand-split foot malformation · score 0.43
- chronic lymphocytic leukemia · score 0.42
- testosterone measurement · score 0.42
- hair color · score 0.41
- systolic blood pressure · score 0.41
- hair colour measurement · score 0.40
- appendicular lean mass · score 0.38
- pancreatic ductal adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJU2-F1 | alphafold | PREDICTED | 57.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJU2.
Amino-acid sequence (399 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LEF1?
The strongest Open Targets associations for LEF1 are Ectrodactyly, split hand-foot malformation, Split hand-split foot malformation, chronic lymphocytic leukemia and testosterone measurement.
How long is the LEF1 protein?
The Homo sapiens LEF1 protein (UniProt Q9UJU2) is 399 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJU2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJU2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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