Forkhead box protein D3 (FOXD3)
Homo sapiens — UniProt Q9UJU5
Data last refreshed: (UniProt release unknown)
Key facts
Forkhead box protein D3 (FOXD3) is a protein from Homo sapiens identified by UniProt accession Q9UJU5, 478 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q9UJU5; gene symbol FOXD3.
- Organism: Homo sapiens.
- Length: 478 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Aniridia and aniridia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Forkhead box protein D3 |
|---|---|
| UniProt accession | Q9UJU5 |
| Gene | FOXD3 |
| Organism | Homo sapiens |
| Length | 478 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- Aniridia · score 0.42
- aniridia · score 0.42
- anterior segment dysgenesis · score 0.42
- Peters anomaly · score 0.42
- appendicular lean mass · score 0.37
- body height · score 0.32
- cutaneous melanoma · score 0.26
- skin pigmentation · score 0.25
- sitting height measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJU5-F1 | alphafold | PREDICTED | 55.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJU5.
Amino-acid sequence (478 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FOXD3?
The strongest Open Targets associations for FOXD3 are neurodegenerative disease, Aniridia, aniridia, anterior segment dysgenesis and Peters anomaly.
How long is the FOXD3 protein?
The Homo sapiens FOXD3 protein (UniProt Q9UJU5) is 478 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJU5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJU5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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