Probable E3 ubiquitin-protein ligase MID2 (MID2)
Homo sapiens — UniProt Q9UJV3
Data last refreshed: (UniProt release unknown)
Key facts
Probable E3 ubiquitin-protein ligase MID2 (MID2) is a protein from Homo sapiens identified by UniProt accession Q9UJV3, 735 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q9UJV3; gene symbol MID2.
- Organism: Homo sapiens.
- Length: 735 amino acids.
- Top disease associations (Open Targets): X-linked non-syndromic intellectual disability, pyloric stenosis and Esophageal atresia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable E3 ubiquitin-protein ligase MID2 |
|---|---|
| UniProt accession | Q9UJV3 |
| Gene | MID2 |
| Organism | Homo sapiens |
| Length | 735 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.62
- pyloric stenosis · score 0.11
- Esophageal atresia · score 0.11
- triple-negative breast cancer · score 0.07
- colorectal carcinoma · score 0.07
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.04
- cancer · score 0.04
- hereditary elliptocytosis · score 0.04
- hemoglobin H disease · score 0.03
- peeling skin syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJV3-F1 | alphafold | PREDICTED | 79.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJV3.
Amino-acid sequence (735 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MID2?
The strongest Open Targets associations for MID2 are X-linked non-syndromic intellectual disability, pyloric stenosis, Esophageal atresia, triple-negative breast cancer and colorectal carcinoma.
How long is the MID2 protein?
The Homo sapiens MID2 protein (UniProt Q9UJV3) is 735 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJV3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJV3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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