Probable ATP-dependent RNA helicase DDX41 (DDX41)
Homo sapiens — UniProt Q9UJV9
Data last refreshed: (UniProt release unknown)
Key facts
Probable ATP-dependent RNA helicase DDX41 (DDX41) is a protein from Homo sapiens identified by UniProt accession Q9UJV9, 622 residues long. MolForge cross-references it against 0 known binders and 345 disease associations.
- UniProt accession: Q9UJV9; gene symbol DDX41.
- Organism: Homo sapiens.
- Length: 622 amino acids.
- Top disease associations (Open Targets): DDX41-related hematologic malignancy predisposition syndrome, acute myeloid leukemia and myelodysplastic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX41 |
|---|---|
| UniProt accession | Q9UJV9 |
| Gene | DDX41 |
| Organism | Homo sapiens |
| Length | 622 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (345)
Diseases linked to this target (Open Targets).
- DDX41-related hematologic malignancy predisposition syndrome · score 0.79
- acute myeloid leukemia · score 0.71
- myelodysplastic syndrome · score 0.68
- refractory anemia with excess blasts · score 0.58
- myeloid leukemia · score 0.55
- neurodegenerative disease · score 0.51
- adult acute myeloid leukemia · score 0.49
- chronic myelogenous leukemia · score 0.46
- Deafness - lymphedema - leukemia · score 0.45
- genetic disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJV9-F1 | alphafold | PREDICTED | 77.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJV9.
Amino-acid sequence (622 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX41?
The strongest Open Targets associations for DDX41 are DDX41-related hematologic malignancy predisposition syndrome, acute myeloid leukemia, myelodysplastic syndrome, refractory anemia with excess blasts and myeloid leukemia.
How long is the DDX41 protein?
The Homo sapiens DDX41 protein (UniProt Q9UJV9) is 622 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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