Dynactin subunit 4 (DCTN4)
Homo sapiens — UniProt Q9UJW0
Data last refreshed: (UniProt release unknown)
Key facts
Dynactin subunit 4 (DCTN4) is a protein from Homo sapiens identified by UniProt accession Q9UJW0, 460 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q9UJW0; gene symbol DCTN4.
- Organism: Homo sapiens.
- Length: 460 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cystic fibrosis and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynactin subunit 4 |
|---|---|
| UniProt accession | Q9UJW0 |
| Gene | DCTN4 |
| Organism | Homo sapiens |
| Length | 460 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- cystic fibrosis · score 0.38
- breast adenocarcinoma · score 0.10
- hypertriglyceridemia 2 · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- glioblastoma multiforme · score 0.03
- colon adenocarcinoma · score 0.02
- neoplasm · score 0.02
- laryngeal squamous cell carcinoma · score 0.02
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJW0-F1 | alphafold | PREDICTED | 84.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJW0.
Amino-acid sequence (460 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCTN4?
The strongest Open Targets associations for DCTN4 are neurodegenerative disease, cystic fibrosis, breast adenocarcinoma, hypertriglyceridemia 2 and cholesterol-ester transfer protein deficiency.
How long is the DCTN4 protein?
The Homo sapiens DCTN4 protein (UniProt Q9UJW0) is 460 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJW0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJW0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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