DNA (cytosine-5)-methyltransferase 3-like (DNMT3L)
Homo sapiens — UniProt Q9UJW3
Data last refreshed: (UniProt release unknown)
Key facts
DNA (cytosine-5)-methyltransferase 3-like (DNMT3L) is a protein from Homo sapiens identified by UniProt accession Q9UJW3, 386 residues long. MolForge cross-references it against 0 known binders and 219 disease associations.
- UniProt accession: Q9UJW3; gene symbol DNMT3L.
- Organism: Homo sapiens.
- Length: 386 amino acids.
- Top disease associations (Open Targets): eosinophil count, eosinophil percentage of granulocytes and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA (cytosine-5)-methyltransferase 3-like |
|---|---|
| UniProt accession | Q9UJW3 |
| Gene | DNMT3L |
| Organism | Homo sapiens |
| Length | 386 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (219)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.27
- eosinophil percentage of granulocytes · score 0.14
- endometrial cancer · score 0.11
- eosinophil percentage of leukocytes · score 0.10
- azoospermia · score 0.10
- sum of eosinophil and basophil counts · score 0.10
- Female infertility due to fertilization defect · score 0.09
- partial chromosome Y deletion · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- Rare genetic female infertility · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJW3-F1 | alphafold | PREDICTED | 86.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJW3.
Amino-acid sequence (386 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNMT3L?
The strongest Open Targets associations for DNMT3L are eosinophil count, eosinophil percentage of granulocytes, endometrial cancer, eosinophil percentage of leukocytes and azoospermia.
How long is the DNMT3L protein?
The Homo sapiens DNMT3L protein (UniProt Q9UJW3) is 386 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJW3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJW3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.