Heat shock protein beta-8 (HSPB8)
Homo sapiens — UniProt Q9UJY1
Data last refreshed: (UniProt release unknown)
Key facts
Heat shock protein beta-8 (HSPB8) is a protein from Homo sapiens identified by UniProt accession Q9UJY1, 196 residues long. MolForge cross-references it against 0 known binders and 282 disease associations.
- UniProt accession: Q9UJY1; gene symbol HSPB8.
- Organism: Homo sapiens.
- Length: 196 amino acids.
- Top disease associations (Open Targets): neuronopathy, distal hereditary motor, type 2A, Charcot-Marie-Tooth disease axonal type 2L and Autosomal dominant Charcot-Marie-Tooth disease type 2L.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Heat shock protein beta-8 |
|---|---|
| UniProt accession | Q9UJY1 |
| Gene | HSPB8 |
| Organism | Homo sapiens |
| Length | 196 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (282)
Diseases linked to this target (Open Targets).
- neuronopathy, distal hereditary motor, type 2A · score 0.77
- Charcot-Marie-Tooth disease axonal type 2L · score 0.69
- Autosomal dominant Charcot-Marie-Tooth disease type 2L · score 0.64
- Charcot-Marie-Tooth disease · score 0.52
- distal myopathy · score 0.44
- neuronopathy, distal hereditary motor, autosomal dominant · score 0.37
- distal hereditary motor neuropathy type 2 · score 0.37
- genetic disorder · score 0.34
- PR interval · score 0.32
- distal hereditary motor neuropathy · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJY1-F1 | alphafold | PREDICTED | 68.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJY1.
Amino-acid sequence (196 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HSPB8?
The strongest Open Targets associations for HSPB8 are neuronopathy, distal hereditary motor, type 2A, Charcot-Marie-Tooth disease axonal type 2L, Autosomal dominant Charcot-Marie-Tooth disease type 2L, Charcot-Marie-Tooth disease and distal myopathy.
How long is the HSPB8 protein?
The Homo sapiens HSPB8 protein (UniProt Q9UJY1) is 196 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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