ADP-ribosylation factor-binding protein GGA2 (GGA2)
Homo sapiens — UniProt Q9UJY4
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribosylation factor-binding protein GGA2 (GGA2) is a protein from Homo sapiens identified by UniProt accession Q9UJY4, 613 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9UJY4; gene symbol GGA2.
- Organism: Homo sapiens.
- Length: 613 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, glycogen storage disorder due to hepatic glycogen synthase deficiency and Glycogen storage disease due to hepatic glycogen synthase deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribosylation factor-binding protein GGA2 |
|---|---|
| UniProt accession | Q9UJY4 |
| Gene | GGA2 |
| Organism | Homo sapiens |
| Length | 613 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.07
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.03
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.03
- MODY · score 0.03
- exercise-induced hyperinsulinism · score 0.03
- hepatocellular carcinoma · score 0.03
- neoplasm · score 0.02
- mean reticulocyte volume · score 0.02
- cancer · score 0.02
- lung adenocarcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UJY4-F1 | alphafold | PREDICTED | 71.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UJY4.
Amino-acid sequence (613 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GGA2?
The strongest Open Targets associations for GGA2 are mean corpuscular volume, glycogen storage disorder due to hepatic glycogen synthase deficiency, Glycogen storage disease due to hepatic glycogen synthase deficiency, MODY and exercise-induced hyperinsulinism.
How long is the GGA2 protein?
The Homo sapiens GGA2 protein (UniProt Q9UJY4) is 613 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UJY4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UJY4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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