Vacuolar protein sorting-associated protein 28 homolog (VPS28)
Homo sapiens — UniProt Q9UK41
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 28 homolog (VPS28) is a protein from Homo sapiens identified by UniProt accession Q9UK41, 221 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q9UK41; gene symbol VPS28.
- Organism: Homo sapiens.
- Length: 221 amino acids.
- Top disease associations (Open Targets): HIV infection, viral disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 28 homolog |
|---|---|
| UniProt accession | Q9UK41 |
| Gene | VPS28 |
| Organism | Homo sapiens |
| Length | 221 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.53
- viral disease · score 0.46
- Alzheimer disease · score 0.41
- Parkinson disease · score 0.41
- lysosomal storage disease · score 0.41
- neurodegenerative disease · score 0.41
- multiple sclerosis · score 0.41
- clear cell renal carcinoma · score 0.17
- mean corpuscular volume · score 0.16
- sex hormone-binding globulin measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UK41-F1 | alphafold | PREDICTED | 91.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UK41.
Amino-acid sequence (221 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS28?
The strongest Open Targets associations for VPS28 are HIV infection, viral disease, Alzheimer disease, Parkinson disease and lysosomal storage disease.
How long is the VPS28 protein?
The Homo sapiens VPS28 protein (UniProt Q9UK41) is 221 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UK41 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UK41 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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