F-box/LRR-repeat protein 5 (FBXL5)
Homo sapiens — UniProt Q9UKA1
Data last refreshed: (UniProt release unknown)
Key facts
F-box/LRR-repeat protein 5 (FBXL5) is a protein from Homo sapiens identified by UniProt accession Q9UKA1, 691 residues long. MolForge cross-references it against 0 known binders and 180 disease associations.
- UniProt accession: Q9UKA1; gene symbol FBXL5.
- Organism: Homo sapiens.
- Length: 691 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, erythrocyte count and ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/LRR-repeat protein 5 |
|---|---|
| UniProt accession | Q9UKA1 |
| Gene | FBXL5 |
| Organism | Homo sapiens |
| Length | 691 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (180)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- erythrocyte count · score 0.38
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 measurement · score 0.35
- self reported educational attainment · score 0.33
- mean corpuscular volume · score 0.33
- urinary metabolite measurement · score 0.30
- pancreatic adenocarcinoma · score 0.27
- glioblastoma multiforme · score 0.25
- mathematical ability · score 0.25
- lung adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKA1-F1 | alphafold | PREDICTED | 69.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKA1.
Amino-acid sequence (691 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXL5?
The strongest Open Targets associations for FBXL5 are neurodegenerative disease, erythrocyte count, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 measurement, self reported educational attainment and mean corpuscular volume.
How long is the FBXL5 protein?
The Homo sapiens FBXL5 protein (UniProt Q9UKA1) is 691 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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