A-kinase anchor protein 11 (AKAP11)
Homo sapiens — UniProt Q9UKA4
Data last refreshed: (UniProt release unknown)
Key facts
A-kinase anchor protein 11 (AKAP11) is a protein from Homo sapiens identified by UniProt accession Q9UKA4, 1901 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.
- UniProt accession: Q9UKA4; gene symbol AKAP11.
- Organism: Homo sapiens.
- Length: 1901 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A-kinase anchor protein 11 |
|---|---|
| UniProt accession | Q9UKA4 |
| Gene | AKAP11 |
| Organism | Homo sapiens |
| Length | 1901 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (102)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- Parkinson disease · score 0.50
- lysosomal storage disease · score 0.50
- multiple sclerosis · score 0.50
- Alzheimer disease · score 0.50
- neutrophil count · score 0.39
- neuroinflammatory disorder · score 0.37
- bone quantitative ultrasound measurement · score 0.36
- type 1 diabetes mellitus · score 0.36
- bone density · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKA4-F1 | alphafold | PREDICTED | 45.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKA4.
Amino-acid sequence (1901 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AKAP11?
The strongest Open Targets associations for AKAP11 are neurodegenerative disease, Parkinson disease, lysosomal storage disease, multiple sclerosis and Alzheimer disease.
How long is the AKAP11 protein?
The Homo sapiens AKAP11 protein (UniProt Q9UKA4) is 1901 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKA4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKA4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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