Polypyrimidine tract-binding protein 2 (PTBP2)
Homo sapiens — UniProt Q9UKA9
Data last refreshed: (UniProt release unknown)
Key facts
Polypyrimidine tract-binding protein 2 (PTBP2) is a protein from Homo sapiens identified by UniProt accession Q9UKA9, 531 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.
- UniProt accession: Q9UKA9; gene symbol PTBP2.
- Organism: Homo sapiens.
- Length: 531 amino acids.
- Top disease associations (Open Targets): lean body mass, fat body mass and anorexia nervosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polypyrimidine tract-binding protein 2 |
|---|---|
| UniProt accession | Q9UKA9 |
| Gene | PTBP2 |
| Organism | Homo sapiens |
| Length | 531 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (164)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.33
- fat body mass · score 0.30
- anorexia nervosa · score 0.30
- body mass index · score 0.29
- reaction time measurement · score 0.29
- body fat percentage · score 0.26
- schizophrenia · score 0.26
- chronotype measurement · score 0.26
- snoring measurement · score 0.25
- cystatin C measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKA9-F1 | alphafold | PREDICTED | 72.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKA9.
Amino-acid sequence (531 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTBP2?
The strongest Open Targets associations for PTBP2 are lean body mass, fat body mass, anorexia nervosa, body mass index and reaction time measurement.
How long is the PTBP2 protein?
The Homo sapiens PTBP2 protein (UniProt Q9UKA9) is 531 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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