F-box/WD repeat-containing protein 11 (FBXW11)
Homo sapiens — UniProt Q9UKB1
Data last refreshed: (UniProt release unknown)
Key facts
F-box/WD repeat-containing protein 11 (FBXW11) is a protein from Homo sapiens identified by UniProt accession Q9UKB1, 542 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q9UKB1; gene symbol FBXW11.
- Organism: Homo sapiens.
- Length: 542 amino acids.
- Top disease associations (Open Targets): neurodevelopmental, jaw, eye, and digital syndrome, neurodegenerative disease and syndromic intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/WD repeat-containing protein 11 |
|---|---|
| UniProt accession | Q9UKB1 |
| Gene | FBXW11 |
| Organism | Homo sapiens |
| Length | 542 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- neurodevelopmental, jaw, eye, and digital syndrome · score 0.70
- neurodegenerative disease · score 0.50
- syndromic intellectual disability · score 0.46
- complex neurodevelopmental disorder · score 0.37
- ovarian cancer · score 0.26
- glioblastoma multiforme · score 0.25
- clear cell renal carcinoma · score 0.18
- body height · score 0.12
- BMI-adjusted waist circumference · score 0.12
- lean body mass · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKB1-F1 | alphafold | PREDICTED | 85.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKB1.
Amino-acid sequence (542 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXW11?
The strongest Open Targets associations for FBXW11 are neurodevelopmental, jaw, eye, and digital syndrome, neurodegenerative disease, syndromic intellectual disability, complex neurodevelopmental disorder and ovarian cancer.
How long is the FBXW11 protein?
The Homo sapiens FBXW11 protein (UniProt Q9UKB1) is 542 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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