F-box/LRR-repeat protein 2 (FBXL2)
Homo sapiens — UniProt Q9UKC9
Data last refreshed: (UniProt release unknown)
Key facts
F-box/LRR-repeat protein 2 (FBXL2) is a protein from Homo sapiens identified by UniProt accession Q9UKC9, 423 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.
- UniProt accession: Q9UKC9; gene symbol FBXL2.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, Blackfan-Diamond anemia and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/LRR-repeat protein 2 |
|---|---|
| UniProt accession | Q9UKC9 |
| Gene | FBXL2 |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (116)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.10
- Blackfan-Diamond anemia · score 0.09
- neoplasm · score 0.07
- non-small cell lung carcinoma · score 0.07
- blood protein measurement · score 0.07
- forced expiratory volume · score 0.07
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.07
- alpha-thalassemia-myelodysplastic syndrome · score 0.07
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKC9-F1 | alphafold | PREDICTED | 92.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKC9.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXL2?
The strongest Open Targets associations for FBXL2 are heel bone mineral density, Blackfan-Diamond anemia, neoplasm, non-small cell lung carcinoma and blood protein measurement.
How long is the FBXL2 protein?
The Homo sapiens FBXL2 protein (UniProt Q9UKC9) is 423 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKC9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKC9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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