TRAF2 and NCK-interacting protein kinase (TNIK)
Homo sapiens — UniProt Q9UKE5
Data last refreshed: (UniProt release unknown)
Key facts
TRAF2 and NCK-interacting protein kinase (TNIK) is a protein from Homo sapiens identified by UniProt accession Q9UKE5, 1360 residues long. MolForge cross-references it against 18 known binders and 140 disease associations.
- UniProt accession: Q9UKE5; gene symbol TNIK.
- Organism: Homo sapiens.
- Length: 1360 amino acids.
- Target class: Kinase.
- Top disease associations (Open Targets): neurodegenerative disease, autosomal recessive non-syndromic intellectual disability and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TRAF2 and NCK-interacting protein kinase |
|---|---|
| UniProt accession | Q9UKE5 |
| Gene | TNIK |
| Organism | Homo sapiens |
| Length | 1360 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Kinase (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (140)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- autosomal recessive non-syndromic intellectual disability · score 0.49
- lymphocyte count · score 0.46
- body mass index · score 0.45
- lymphocyte percentage of leukocytes · score 0.37
- brain measurement · score 0.37
- cortical surface area measurement · score 0.37
- neuroimaging measurement · score 0.36
- arterial stiffness measurement · score 0.32
- hair colour measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKE5-F1 | alphafold | PREDICTED | 63.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKE5.
Amino-acid sequence (1360 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TNIK?
The strongest Open Targets associations for TNIK are neurodegenerative disease, autosomal recessive non-syndromic intellectual disability, lymphocyte count, body mass index and lymphocyte percentage of leukocytes.
How long is the TNIK protein?
The Homo sapiens TNIK protein (UniProt Q9UKE5) is 1360 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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