Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)
Homo sapiens — UniProt Q9UKF6
Data last refreshed: (UniProt release unknown)
Key facts
Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) is a protein from Homo sapiens identified by UniProt accession Q9UKF6, 684 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q9UKF6; gene symbol CPSF3.
- Organism: Homo sapiens.
- Length: 684 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures, neurodegenerative disease and neurodevelopmental disorder with hypotonia, microcephaly, and seizures.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cleavage and polyadenylation specificity factor subunit 3 |
|---|---|
| UniProt accession | Q9UKF6 |
| Gene | CPSF3 |
| Organism | Homo sapiens |
| Length | 684 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures · score 0.54
- neurodegenerative disease · score 0.53
- neurodevelopmental disorder with hypotonia, microcephaly, and seizures · score 0.42
- complex neurodevelopmental disorder · score 0.37
- body height · score 0.10
- hepatocellular carcinoma · score 0.09
- mean platelet volume · score 0.08
- lung adenocarcinoma · score 0.08
- tumor necrosis factor receptor 1 measurement · score 0.07
- breast cancer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKF6-F1 | alphafold | PREDICTED | 90.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKF6.
Amino-acid sequence (684 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CPSF3?
The strongest Open Targets associations for CPSF3 are neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures, neurodegenerative disease, neurodevelopmental disorder with hypotonia, microcephaly, and seizures, complex neurodevelopmental disorder and body height.
How long is the CPSF3 protein?
The Homo sapiens CPSF3 protein (UniProt Q9UKF6) is 684 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKF6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKF6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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