DCC-interacting protein 13-alpha (APPL1)
Homo sapiens — UniProt Q9UKG1
Data last refreshed: (UniProt release unknown)
Key facts
DCC-interacting protein 13-alpha (APPL1) is a protein from Homo sapiens identified by UniProt accession Q9UKG1, 709 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.
- UniProt accession: Q9UKG1; gene symbol APPL1.
- Organism: Homo sapiens.
- Length: 709 amino acids.
- Top disease associations (Open Targets): MODY, neurodegenerative disease and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DCC-interacting protein 13-alpha |
|---|---|
| UniProt accession | Q9UKG1 |
| Gene | APPL1 |
| Organism | Homo sapiens |
| Length | 709 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (146)
Diseases linked to this target (Open Targets).
- MODY · score 0.64
- neurodegenerative disease · score 0.29
- breast adenocarcinoma · score 0.24
- glioblastoma multiforme · score 0.23
- low grade glioma · score 0.23
- insulin like growth factor measurement · score 0.16
- IGF-1 measurement · score 0.16
- cutaneous melanoma · score 0.15
- esophageal cancer · score 0.15
- hepatocellular carcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKG1-F1 | alphafold | PREDICTED | 80.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKG1.
Amino-acid sequence (709 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with APPL1?
The strongest Open Targets associations for APPL1 are MODY, neurodegenerative disease, breast adenocarcinoma, glioblastoma multiforme and low grade glioma.
How long is the APPL1 protein?
The Homo sapiens APPL1 protein (UniProt Q9UKG1) is 709 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKG1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKG1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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