Peroxisomal carnitine O-octanoyltransferase (CROT)
Homo sapiens — UniProt Q9UKG9
Data last refreshed: (UniProt release unknown)
Key facts
Peroxisomal carnitine O-octanoyltransferase (CROT) is a protein from Homo sapiens identified by UniProt accession Q9UKG9, 612 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9UKG9; gene symbol CROT.
- Organism: Homo sapiens.
- Length: 612 amino acids.
- Top disease associations (Open Targets): blood protein measurement, Red cell distribution width and sex hormone-binding globulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peroxisomal carnitine O-octanoyltransferase |
|---|---|
| UniProt accession | Q9UKG9 |
| Gene | CROT |
| Organism | Homo sapiens |
| Length | 612 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.37
- Red cell distribution width · score 0.32
- sex hormone-binding globulin measurement · score 0.28
- neurodegenerative disease · score 0.19
- PHF-tau measurement · score 0.13
- ringed hair disease · score 0.08
- Griscelli syndrome type 3 · score 0.08
- uncombable hair syndrome · score 0.08
- aspartate aminotransferase measurement · score 0.07
- Griscelli disease · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKG9-F1 | alphafold | PREDICTED | 97.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKG9.
Amino-acid sequence (612 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CROT?
The strongest Open Targets associations for CROT are blood protein measurement, Red cell distribution width, sex hormone-binding globulin measurement, neurodegenerative disease and PHF-tau measurement.
How long is the CROT protein?
The Homo sapiens CROT protein (UniProt Q9UKG9) is 612 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKG9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKG9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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