Serine/threonine-protein kinase tousled-like 1 (TLK1)
Homo sapiens — UniProt Q9UKI8
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase tousled-like 1 (TLK1) is a protein from Homo sapiens identified by UniProt accession Q9UKI8, 766 residues long. MolForge cross-references it against 5 known binders and 103 disease associations.
- UniProt accession: Q9UKI8; gene symbol TLK1.
- Organism: Homo sapiens.
- Length: 766 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body height and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase tousled-like 1 |
|---|---|
| UniProt accession | Q9UKI8 |
| Gene | TLK1 |
| Organism | Homo sapiens |
| Length | 766 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- body height · score 0.42
- platelet count · score 0.34
- mean platelet volume · score 0.33
- age at menopause · score 0.31
- vital capacity · score 0.29
- forced expiratory volume · score 0.27
- platelet component distribution width · score 0.26
- appendicular lean mass · score 0.26
- mathematical ability · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKI8-F1 | alphafold | PREDICTED | 72.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKI8.
Amino-acid sequence (766 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TLK1?
The strongest Open Targets associations for TLK1 are neurodegenerative disease, body height, platelet count, mean platelet volume and age at menopause.
How long is the TLK1 protein?
The Homo sapiens TLK1 protein (UniProt Q9UKI8) is 766 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKI8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKI8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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