G patch domain-containing protein 8 (GPATCH8)

Homo sapiens — UniProt Q9UKJ3

Gene: GPATCH8Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

G patch domain-containing protein 8 (GPATCH8) is a protein from Homo sapiens identified by UniProt accession Q9UKJ3, 1502 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

UniProt accession: Q9UKJ3; gene symbol GPATCH8.
Organism: Homo sapiens.
Length: 1502 amino acids.
Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and platelet count.
3D structure: AlphaFold model available.

Target properties

Protein name	G patch domain-containing protein 8
UniProt accession	Q9UKJ3
Gene	GPATCH8
Organism	Homo sapiens
Length	1502 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
lysosomal storage disease · score 0.22
platelet count · score 0.16
brain measurement · score 0.14
neuroimaging measurement · score 0.14
platelet crit · score 0.10
mean platelet volume · score 0.07
mental or behavioural disorder · score 0.05
drug use measurement · score 0.03
Alzheimer disease · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UKJ3-F1	alphafold	PREDICTED	45.69	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKJ3.

Amino-acid sequence (1502 residues)

MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK HGWKLGQGLG KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV LEVEKEDTEE LRQKYKDYVD KEKAIAKALE DLRANFYCEL CDKQYQKHQE FDNHINSYDH AHKQRLKDLK QREFARNVSS RSRKDEKKQE KALRRLHELA EQRKQAECAP GSGPMFKPTT VAVDEEGGED DKDESATNSG TGATASCGLG SEFSTDKGGP FTAVQITNTT GLAQAPGLAS QGISFGIKNN LGTPLQKLGV SFSFAKKAPV KLESIASVFK DHAEEGTSED GTKPDEKSSD QGLQKVGDSD GSSNLDGKKE DEDPQDGGSL ASTLSKLKRM KREEGAGATE PEYYHYIPPA HCKVKPNFPF LLFMRASEQM DGDNTTHPKN APESKKGSSP KPKSCIKAAA SQGAEKTVSE VSEQPKETSM TEPSEPGSKA EAKKALGGDV SDQSLESHSQ KVSETQMCES NSSKETSLAT PAGKESQEGP KHPTGPFFPV LSKDESTALQ WPSELLIFTK AEPSISYSCN PLYFDFKLSR NKDARTKGTE KPKDIGSSSK DHLQGLDPGE PNKSKEVGGE KIVRSSGGRM DAPASGSACS GLNKQEPGGS HGSETEDTGR SLPSKKERSG KSHRHKKKKK HKKSSKHKRK HKADTEEKSS KAESGEKSKK RKKRKRKKNK SSAPADSERG PKPEPPGSGS PAPPRRRRRA QDDSQRRSLP AEEGSSGKKD EGGGGSSSQD HGGRKHKGEL PPSSCQRRAG TKRSSRSSHR SQPSSGDEDS DDASSHRLHQ KSPSQYSEEE EEEDSGSEHS RSRSRSGRRH SSHRSSRRSY SSSSDASSDQ SCYSRQRSYS DDSYSDYSDR SRRHSKRSHD SDDSDYASSK HRSKRHKYSS SDDDYSLSCS QSRSRSRSHT RERSRSRGRS RSSSCSRSRS KRRSRSTTAH SWQRSRSYSR DRSRSTRSPS QRSGSRKRSW GHESPEERHS GRRDFIRSKI YRSQSPHYFR SGRGEGPGKK DDGRGDDSKA TGPPSQNSNI GTGRGSEGDC SPEDKNSVTA KLLLEKIQSR KVERKPSVSE EVQATPNKAG PKLKDPPQGY FGPKLPPSLG NKPVLPLIGK LPATRKPNKK CEESGLERGE EQEQSETEEG PPGSSDALFG HQFPSEETTG PLLDPPPEES KSGEATADHP VAPLGTPAHS DCYPGDPTIS HNYLPDPSDG DTLESLDSSS QPGPVESSLL PIAPDLEHFP SYAPPSGDPS IESTDGAEDA SLAPLESQPI TFTPEEMEKY SKLQQAAQQH IQQQLLAKQV KAFPASAALA PATPALQPIH IQQPATASAT SITTVQHAIL QHHAAAAAAA IGIHPHPHPQ PLAQVHHIPQ PHLTPISLSH LTHSIIPGHP ATFLASHPIH IIPASAIHPG PFTFHPVPHA ALYPTLLAPR PAAAAATALH LHPLLHPIFS GQDLQHPPSH GT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with GPATCH8?

The strongest Open Targets associations for GPATCH8 are neurodegenerative disease, lysosomal storage disease, platelet count, brain measurement and neuroimaging measurement.

How long is the GPATCH8 protein?

The Homo sapiens GPATCH8 protein (UniProt Q9UKJ3) is 1502 amino acids long.

Browse: Targets: G · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9UKJ3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9UKJ3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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