Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2)
Homo sapiens — UniProt Q9UKJ5
Data last refreshed: (UniProt release unknown)
Key facts
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) is a protein from Homo sapiens identified by UniProt accession Q9UKJ5, 165 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.
- UniProt accession: Q9UKJ5; gene symbol CHIC2.
- Organism: Homo sapiens.
- Length: 165 amino acids.
- Top disease associations (Open Targets): pulse pressure measurement, systolic blood pressure and alcohol drinking.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cysteine-rich hydrophobic domain-containing protein 2 |
|---|---|
| UniProt accession | Q9UKJ5 |
| Gene | CHIC2 |
| Organism | Homo sapiens |
| Length | 165 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (140)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.45
- systolic blood pressure · score 0.39
- alcohol drinking · score 0.39
- diastolic blood pressure · score 0.37
- neuroimaging measurement · score 0.35
- brain measurement · score 0.33
- brain volume measurement · score 0.31
- neurodegenerative disease · score 0.30
- cortical surface area measurement · score 0.29
- alcohol consumption measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKJ5-F1 | alphafold | PREDICTED | 84.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKJ5.
Amino-acid sequence (165 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHIC2?
The strongest Open Targets associations for CHIC2 are pulse pressure measurement, systolic blood pressure, alcohol drinking, diastolic blood pressure and neuroimaging measurement.
How long is the CHIC2 protein?
The Homo sapiens CHIC2 protein (UniProt Q9UKJ5) is 165 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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