Disintegrin and metalloproteinase domain-containing protein 21 (ADAM21)
Homo sapiens — UniProt Q9UKJ8
Data last refreshed: (UniProt release unknown)
Key facts
Disintegrin and metalloproteinase domain-containing protein 21 (ADAM21) is a protein from Homo sapiens identified by UniProt accession Q9UKJ8, 722 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9UKJ8; gene symbol ADAM21.
- Organism: Homo sapiens.
- Length: 722 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, cutaneous melanoma and aspartate aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Disintegrin and metalloproteinase domain-containing protein 21 |
|---|---|
| UniProt accession | Q9UKJ8 |
| Gene | ADAM21 |
| Organism | Homo sapiens |
| Length | 722 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.25
- cutaneous melanoma · score 0.25
- aspartate aminotransferase measurement · score 0.23
- low density lipoprotein cholesterol measurement · score 0.23
- squamous cell lung carcinoma · score 0.18
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.13
- apolipoprotein B measurement · score 0.08
- total cholesterol measurement · score 0.06
- hepatocellular carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKJ8-F1 | alphafold | PREDICTED | 83.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKJ8.
Amino-acid sequence (722 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAM21?
The strongest Open Targets associations for ADAM21 are lung adenocarcinoma, cutaneous melanoma, aspartate aminotransferase measurement, low density lipoprotein cholesterol measurement and squamous cell lung carcinoma.
How long is the ADAM21 protein?
The Homo sapiens ADAM21 protein (UniProt Q9UKJ8) is 722 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKJ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKJ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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