Protein mono-ADP-ribosyltransferase PARP4 (PARP4)
Homo sapiens — UniProt Q9UKK3
Data last refreshed: (UniProt release unknown)
Key facts
Protein mono-ADP-ribosyltransferase PARP4 (PARP4) is a protein from Homo sapiens identified by UniProt accession Q9UKK3, 1724 residues long. MolForge cross-references it against 5 known binders and 46 disease associations.
- UniProt accession: Q9UKK3; gene symbol PARP4.
- Organism: Homo sapiens.
- Length: 1724 amino acids.
- Approved drugs acting on it (DrugCentral): Rucaparib.
- Top disease associations (Open Targets): severe acute respiratory syndrome, COVID-19 and anxiety disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase PARP4 |
|---|---|
| UniProt accession | Q9UKK3 |
| Gene | PARP4 |
| Organism | Homo sapiens |
| Length | 1724 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (46)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- COVID-19 · score 0.37
- anxiety disorder · score 0.30
- lung adenocarcinoma · score 0.23
- colorectal adenocarcinoma · score 0.21
- multiple myeloma · score 0.15
- neurofibrillary tangles measurement · score 0.12
- lateral epicondylitis · score 0.12
- neoplasm · score 0.08
- cholesterol-ester transfer protein deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKK3-F1 | alphafold | PREDICTED | 69.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKK3.
Amino-acid sequence (1724 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target PARP4?
DrugCentral lists 1 approved drug whose mechanism of action is PARP4: Rucaparib.
Which diseases are associated with PARP4?
The strongest Open Targets associations for PARP4 are severe acute respiratory syndrome, COVID-19, anxiety disorder, lung adenocarcinoma and colorectal adenocarcinoma.
How long is the PARP4 protein?
The Homo sapiens PARP4 protein (UniProt Q9UKK3) is 1724 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKK3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKK3 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.