REST corepressor 1 (RCOR1)
Homo sapiens — UniProt Q9UKL0
Data last refreshed: (UniProt release unknown)
Key facts
REST corepressor 1 (RCOR1) is a protein from Homo sapiens identified by UniProt accession Q9UKL0, 485 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q9UKL0; gene symbol RCOR1.
- Organism: Homo sapiens.
- Length: 485 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | REST corepressor 1 |
|---|---|
| UniProt accession | Q9UKL0 |
| Gene | RCOR1 |
| Organism | Homo sapiens |
| Length | 485 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- platelet count · score 0.42
- mean platelet volume · score 0.39
- reticulocyte count · score 0.38
- platelet crit · score 0.37
- Immature Reticulocyte Fraction Measurement · score 0.34
- reticulocyte measurement · score 0.34
- mean reticulocyte volume · score 0.34
- serum non-albumin protein measurement · score 0.27
- blood protein measurement · score 0.27
- Joubert syndrome · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKL0-F1 | alphafold | PREDICTED | 68.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKL0.
Amino-acid sequence (485 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RCOR1?
The strongest Open Targets associations for RCOR1 are platelet count, mean platelet volume, reticulocyte count, platelet crit and Immature Reticulocyte Fraction Measurement.
How long is the RCOR1 protein?
The Homo sapiens RCOR1 protein (UniProt Q9UKL0) is 485 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKL0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKL0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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