Gap junction delta-2 protein (GJD2)
Homo sapiens — UniProt Q9UKL4
Data last refreshed: (UniProt release unknown)
Key facts
Gap junction delta-2 protein (GJD2) is a protein from Homo sapiens identified by UniProt accession Q9UKL4, 321 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.
- UniProt accession: Q9UKL4; gene symbol GJD2.
- Organism: Homo sapiens.
- Length: 321 amino acids.
- Top disease associations (Open Targets): refractive error, Myopia and Abnormality of refraction.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gap junction delta-2 protein |
|---|---|
| UniProt accession | Q9UKL4 |
| Gene | GJD2 |
| Organism | Homo sapiens |
| Length | 321 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- refractive error · score 0.45
- Myopia · score 0.43
- Abnormality of refraction · score 0.36
- refractive error measurement · score 0.35
- age at onset · score 0.35
- Hypermetropia · score 0.33
- axial length measurement · score 0.32
- hyperopia · score 0.24
- self reported educational attainment · score 0.17
- lung adenocarcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9UKL4-F1 | alphafold | PREDICTED | 72.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9UKL4.
Amino-acid sequence (321 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GJD2?
The strongest Open Targets associations for GJD2 are refractive error, Myopia, Abnormality of refraction, refractive error measurement and age at onset.
How long is the GJD2 protein?
The Homo sapiens GJD2 protein (UniProt Q9UKL4) is 321 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9UKL4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9UKL4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.